Computer simulations show that an unstructured neural-network model [Shultz, T. R., & Bale, A. C. (2001). Infancy, 2, 501–536] covers the essential features␣of infant learning of simple grammars in an artificial language [Marcus, G. F., Vijayan, S., Bandi Rao, S., & Vishton, P. M. (1999). Science, 283, 77–80], and generalizes to examples both outside and inside of the range of training sentences. Knowledge-representation analyses confirm that these networks discover that duplicate words in the sentences are nearly identical and that (...) they use this near-identity relation to distinguish sentences that are consistent or inconsistent with a familiar grammar. Recent simulations that were claimed to show that this model did not really learn these grammars [Vilcu, M., & Hadley, R. F. (2005). Minds and Machines, 15, 359–382] confounded syntactic types with speech sounds and did not perform standard statistical tests of results. (shrink)

The apolipoprotein E gene plays an important role in the pathogenesis of Alzheimer's disease , and amyloid plaque comprised mostly of the amyloid-beta peptide ) is one of the major hallmarks of AD. However, the relationship between these two important molecules is poorly understood. We examined how A treatment affects APOE expression in cultured cells and tested the role of the transcription factor NF-B in APOE gene regulation. To delineate NF-B's role, we have characterized a 1098 nucleotide segment containing the (...) 5'-flanking region of the human APOE gene . Sequence analysis of this region suggests the presence of two potential NF-B elements. To demonstrate promoter activity, the region was cloned upstream of a promoterless luciferase gene. This segment was able to drive expression of luciferase in transient transfections of human fetal glial cells. Promoter activity was stimulated twofold by A treatment. Pretreatment with double-stranded DNA decoy oligonucleotides against NF-B reduced A stimulation. Deletion and mutagenetic analyses demonstrated that the distal NF-B element was functional and showed a strong DNA-protein complex band in gel shift analysis, similar to that from control NF-B consensus element. An anti-inflammatory and anti-NF-B drug, sodium salicylate, significantly blocked A-induced APOE promoter function. Our data provide evidence that upregulation of APOE by A in astroglial cells is mediated by an NF-B-element present in the 5'-flanking region of the APOE gene. (shrink)

Are fictional characters such as Sherlock Holmes real? What can fiction tell us about the nature of truth and reality? In this excellent introduction to the problem of fictionalism R. M. Sainsbury covers the following key topics: what is fiction? realism about fictional objects, including the arguments that fictional objects are real but non-existent; real but non-factual; real but non-concrete the relationship between fictional characters and non-actual worlds fictional entities as abstract artefacts fiction and intentionality and the problem of irrealism (...) fictionalism about possible worlds moral fictionalism. R. M. Sainsbury makes extensive use of examples from fiction, such as Sherlock Holmes, Anna Karenina and Madame Bovary and examines the work of philosophers who have made significant contributions to the topic, including Meinong, David Lewis, and Bas Van Fraassen. Additional features include chapter summaries, annotated further reading and a glossary of technical terms, making _Fiction and Fictionalism_ ideal for those coming to the issue for the first time. (shrink)

This book is available either individually, or as part of the specially-priced Arguments of the Philosphers Collection.

In the early part of the paper, I attempt to explain a dispute between two parties who endorse the compositionality of language but disagree about its implications: Paul Horwich, and Jerry Fodor and Ernest Lepore. In the remainder of the paper, I challenge the thesis on which they are agreed, that compositionality can be taken for granted. I suggest that it is not clear what compositionality involves nor whether it obtains. I consider some kinds of apparent counterexamples, and compositionalist responses (...) to them in terms of covert indexicality and unspecific meanings. I argue that the last option is the best for most of the cases I consider. I conclude by stressing, as against Horwich and Fodor and Lepore, that the appropriate question concerns the extent to which compositionality obtains in a natural language, rather than whether it obtains or not, so that the answer is essentially messy, requiring detailed consideration of a wide range of examples. (shrink)

Since the last decades of the 20th century the meaning and content of knowledge has dramatically changed. This necessitates adopting a historical perspective in ap­proa­ching the questions of knowledge. But so far all the efforts of putting knowledge in a historical perspective since Hegel’s historization of Spirit either suffer from the limitations of the presupposition of the One or fail to ground the historicity of knowledge on the history of coming-to-be and passing-away. Moving from Heidegger’s ‘history of Being’ toward the (...) Aristotelian understanding of coming-to-be and passing away as a process of becoming has the potential to open up new avenues in approaching the historical question of knowledge as well as establishing its relation with the never com­plete ground of the entities as its historical a priori condition of possibility. (shrink)

The paper evaluates Hume's alleged projectivism about causation and moral values.

In concluding section 2, chapter VI of part II of [6], Duhem claimed:... the physicist can never subject an isolated hypothesis to experimental test, but only a whole group of hypotheses...... when the experiment is in disagreement with his predictions, what he learns is that at least one of the hypotheses constituting this group is unacceptable and ought to be modified; but the experiment does not designate which one should be changed'.

This paper presents a unifying framework for the study of artificial life, intelIigence and reality. By providing this framework we can give a clear and concise introduction to the fundamental arguments of all three artificial sciences and facilitate the translation of arguments from any one domain to the other two. The framework is based on a variant of functionalism that does not exclude the role of the observer.

Proposed solutions to the problems of this country's health care system range along a spectrum from central planning to free market. Central planners and free market advocates provide various ethical justifications for the policies they propose. The crucial flaw in the philosophical rationale of central planning is failure to distinguish between normative and metanormative principles, which leads to mistaken understanding of the nature of rights. Natural rights, based on the principle of noninterference, provide the link between individual morality and social (...) order. Free markets, the practical expression of natural rights, are uniquely capable of achieving the goals that central planners seek but find beyond their grasp. The history of this country's health care system and the experiences of other nations provide evidence of the superiority of free markets in reaching for the goals of universal access, control of costs, and sustaining the quality of health care. (shrink)

People use words and concepts to refer to things. There are agents who refer, there are acts of referring, and there are tools to refer with: words and concepts. Reference is a relation between people and things, and also between words or concepts and things, and perhaps it involves all three things at once. It is not just any relation between an action or word and a thing; the list of things which can refer, people, words and concepts, is probably (...) not complete ; and a complete account would need to speak of cases in which the reference relation seems to involve three terms in a different way from the one already mentioned. In the philosophy of language, it has been customary to think of reference as a two-place relation, with some object as the second term and a word or phrase as the first. (shrink)

Russell says that logical constructions are fictions. Does this show that he took them not to be real things?

[R. M. Sainsbury] Evans argued that most ordinary proper names were Russellian: to suppose that they have no bearer is to suppose that they have no meaning. The first part of this paper addresses Evans's arguments, and finds them wanting. Evans also claimed that the logical form of some negative existential sentences involves 'really'. One might be tempted by the view, even if one did not accept its Russellian motivation. However, I suggest that Evans gives no adequate account of 'really', (...) and I point to unclarities in Wiggins's similar, but distinct, attempt to use 'really' in the logical form of true negative existentials. /// [David Wiggins] Evans was not wrong to say that the senses of genuine proper names invoke and require objects. Names in fiction or hypothesis mimic such names. Pace Evans, Sainsbury and free logicians, proper names are scopeless. Names create a presumption of existential generalization. In sentences such as 'Vulcan does not really exist', that presumption is bracketed. The sentence specifies by reference to story or report a concept identical with Vulcan and declares it be really uninstantiated. It is explained why this second level view of 'exists' is to be preferred. (shrink)

Many theories provide semantics for English by proxy of semantics for the "logical form" of English sentences. The paper presents a dilemma: if there is no algorithm for moving between English and logical form, English itself has not been given a semantic theory. But if there is an algorithm, it can be incorporated in the theory, which would then apply directly to English. In the worst case, logical form is an obstacle to providing semantics for English. In the best case, (...) it is unnecessary. (shrink)

Understanding has often been regarded as a kind of knowledge. This paper argues that this view is very implausible for understanding words. Instead, a proper account will be of the “analytic-genetic” variety: it will describe immersion in the practice of using a word in such a way that even those not previously equipped with the concepts the word expresses can become immersed. Meeting this condition requires attention to findings in developmental psychology. If you understand a declarative utterance, you thereby know (...) what the speaker said in uttering the words she did. The converse is close to true: if you come to know what a speaker of a declarative utterance has said, then normally you understand the utterance. An example of an abnormal situation would be one in which the speaker’s utterance is in a language you do not understand, but you are authoritatively informed, and so know, what the speaker said. The connection between understanding a whole utterance and knowing something can be preserved by alluding to the basis of the knowledge: it should arise from understanding the words in the utterance, and how they are put together. This leads to a fairly uncontroversial conditional equivalence: (1) If an utterer of an utterance, U, thereby says that p then: (X knows this, on the basis of understanding the words in U and how they are put together) iff (X understands U). The relevant knowledge has no mysteries: it is propositional, typically fully explicit, and is invoked in memory and in reports of speech. The question to be addressed in this paper is whether we can apply this kind of connection between understanding and knowledge to explain what is taken for granted in the equivalence 2 above, namely, the understanding of words. I will suggest that we cannot. Under some idealizations, one can formulate necessarily true equivalences between understanding a word and knowing something, but these equivalences are unilluminating. The knowledge is not of the straightforward kind invoked in connection with whole utterances, and it is mysterious how one might come to possess it. An account of understanding words requires an “analytic-genetic” story, an analysis which offers some philosophical illumination while being consistent with what is known about the genesis of participation in linguistic practices. (shrink)

This belongs to a symposium about Crispin Wright's Truth\nand Objectivity. Wright entertains the "possibility of a\npluralist view of truth." I suggest that this should not\nentail ambiguity in the word "true." For truth to amount to\ndifferent things for different kinds of subject matter no\nmore entails ambiguity than does the fact that existence\namounts to different things for different kinds of entity.\nTurning to cognitive command, I argue that it is trivially\nsatisfied: if I judge that p and you disagree, then under\nsuitable conditions I must (...) take it that something is wrong\nwith your cognitive mechanisms. (shrink)